International Health News

Ulcer Drugs and Manuka Honey

by Hans R. Larsen, MSc ChE

Hans Larsen Perhaps the greatest scam ever perpetrated by the pharmaceutical industry upon an unsuspecting and uninformed public involves a small, spiral-shaped bacterium named Helicobacter pylori.

H. pylori was discovered in April 1982 by two Australian physicians, Dr. Barry Marshall and Dr. Robbin Warren. In 1983 the two doctors proposed that the bacterium is the cause of peptic (duodenal and gastric) ulcers. Dr. Marshall even went so far as to innoculate himself with the bacterium to prove his point(1). The discovery was met by deafening silence from the medical community and created great anxiety within the pharmaceutical industry. At the time, highly profitable antacids such as cimetidine (Tagamet) and ranitidine (Zantac) were used to treat about 90 per cent of all ulcer patients and generated sales income of over $8 billion per year(1,2). Cimetidine and ranitidine do not cure ulcers, but merely mask the symptoms. The relapse rate after cessation of treatment is 50 per cent after six months and as high as 95 per cent after one year(1,3).

Nevertheless, courageous medical researchers took up the challenge and it soon became apparent just how widespread and serious the H. pylori threat is. Not only did research confirm that over 90 per cent of people with peptic ulcers are infected with the bacterium, but it also became clear that H. pylori infections can be eradicated and the vast majority of ulcers cured by a one-week treatment with antibiotics and antibacterials(2,4-9).

It is estimated that about three quarters of the world's population suffer from a H. pylori infection(2). The prevalence is highest among the elderly, the poor, and among people living in unhygienic conditions(2,6,10,11). H. pylori can be transferred from person to person and is often transmitted by parents to their children. It usually stays with its host for life unless eradicated(2).

H. pylori has a strong affinity for the lining of the stomach and recent research has shown that it is the main cause of stomach ulcers(1,2,5,6,9); the use of aspirin and nonsteroidal anti-inflammatory drugs is another important cause(12,13). A H. pylori infection is involved in dyspepsia (indigestion), excess stomach acid, gastritis (inflammation of the stomach lining), and stomach cancer(2,3,6,14-19). H. pylori has also been implicated in coronary heart disease, hypertension, hives (chronic urticaria), rosacea, and Sjogren's syndrome(2,20-22).

There are several simple tests available for diagnosing a H. pylori infection. The [13C]-urea breath test and antibody assays are non-invasive, but an endoscopic biopsy may be required for final diagnosis(3,9,17).

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Drugs for stomach ulcers

A H. pylori infection can be effectively eradicated by a one-week treatment with tetracycline (or amoxillin), metronidazole (or clarithromycin), and bismuth subsalicylate (or subcitrate); some treatment protocols also include omeprazole(4,6,7,9).

Tetracycline is a common antibiotic with the usual undesirable side effects of this type of drug. Metronidazole is an antibacterial which is particularly effective in treating anaerobic, abdominal infections. It is a very powerful drug with nasty side effects. Bismuth subsalicylate (the active ingredient in Pepto-Bismol) is commonly used to relieve indigestion and heartburn and is relatively innocuous(23).

Omeprazole (Losec) suppresses the formation of stomach acid and is commonly used to alleviate ulcer symptoms. Omeprazole interacts with tranquilizers (diazepam) and anticoagulants (warfarin) and has several unpleasant side effects. Like cimetidine and ranitidine, omeprazole can cause impotence and breast enlargement in men(24,25).

Although the chemical "cocktail" required to eradicate H. pylori is by no means without danger it does do the job. It not only eradicates the bacteria in 90 to 98 per cent of all cases, but also results in a permanent cure for ulcers with a relapse rate of less than five per cent(6).

As a matter of fact, the treatment works so well that the U.S. National Institutes of Health (NIH) in 1994 issued an advisory to all American physicians to discontinue the prescription of cimetidine, omeprazole, and ranitidine for their ulcer patients. Instead, the physicians were advised to treat them with the appropriate regimen of antibiotics, antibacterials, and bismuth compounds to eradicate the H. pylori and permanently cure the ulcers(2).

It would appear that both the medical community and the pharmaceutical industry largely ignored the advice by the NIH to the painful and costly detriment of their patients.

A 1995 survey by an Australian physician showed that less than one per cent of 38,000 war veterans with stomach ulcers were receiving the recommended treatment for their condition (tetracycline, metronidazole, and bismuth subcitrate) (26).

The pharmaceutical industry reacted vigorously to the threat posed by the NIH advice to their $8 billion a year antacid market by making a swift deal with the U.S. Federal Drug Administration (FDA) to allow their antiulcer drugs to be sold without a prescription. With this master stroke the drug companies freed medical doctors from the ethical burden of prescribing ineffective, costly drugs while at the same time maintaining or perhaps even expanding their market among the broad segment of the population who had never heard of H. pylori much less the 1994 NIH advice. Not surprisingly, the drug company executive who negotiated the deal with the FDA was later named one of the 25 most successful business men in a 1995 survey by Business Week(27).

The manuka honey cure

Although the eradication of H. pylori and a complete cure of ulcers can now be accomplished by a two-week treatment with pharmaceutical drugs, there are undoubtedly a great many patients who would rather avoid drugs altogether. For them there is exciting news from New Zealand. Professor Peter Molan and colleagues at the University of Waikato has found that certain strains of manuka honey are very effective in completely eradicating H. pylori when tested in the laboratory(28). There is also compelling evidence that manuka is highly effective in inhibiting the growth of Staphylococcus aureus, a feared member of the methicillin-resistant bacteria family (MRSA) of microorganisms often thriving in a hospital environment(29).

Manuka honey is also beneficial in the treatment of gingivitis and periodontal disease, offers relief from sore throaths and like honey in general, helps alleviate indigestion and diarrhea besides serving as a very effective wound dressing and antibacterial agent(28-31). Manuka honey, however, is unique in its ability to completely eradicate H. pylori and this effect is only found in honey from specific geographic areas(32). A preliminary clinical trial of Manuka honey showed that ulcer patients who took 20 g of honey four times daily, one hour before meals and at bedtime, experienced considerably less pain and discomfort than patients who consumed a honey with no antibacterial activity(33).

The mastic gum cure

Almost 20 years ago British physicians reported that mastic gum (a resinous exudate from the stem of Pistacia lenticus found in the eastern Mediterranean) is highly effective in curing peptic (stomach) ulcers with only 1 gram/day for 2 weeks required to effect a cure(34). The curative effect of mastic gum is ascribed to its ability to eradicate H.pylori and was confirmed in a 2010 clinical trial reported by Greek researchers(35).

Mastic gum has numerous other highly desirable properties. It has been found to lower cholesterol and glucose levels in healthy volunteers; it is a powerful antioxidant and anti-inflammatory, has anticancer properties and is effective in the treatment of indigestion and heartburn(36-40).

The bottom line is that ulcer patients need suffer no more, nor spend large sums of money on ineffective antacid drugs for the rest of their lives. An effective, permanent cure is now available, however, you may have to prod your doctor to make sure that you get the full regimen and not just a broad spectrum antibiotic which is ineffective(6). For those with a strong aversion to any kind of pharmaceutical drugs, treatment with a high quality manuka honey or a high quality Chios mastic gum would definitely be worth a try. A detailed blog from a patient who successfully eradicated her H.pylori with mastic gum can be found here.

  1. Alper, Joseph. Ulcers as an infectious disease. Science, Vol. 260, April 9, 1993, pp. 159-60
  2. Vines, Gail. The enemy within. New Scientist, October 15, 1994, pp. 12- 14
  3. Conwell, Carl F., et al. Prevalence of Helicobacter pylori in family practice patients with refractory dyspepsia: a comparison of tests available in the office. The Journal of Family Practice, Vol. 41, No. 3, September 1995, pp. 245-49
  4. Hosking, Shorland W., et al. Duodenal ulcer healing by eradication of Helicobacter pylori without anti-acid treatment: randomised controlled trial. The Lancet, Vol. 343, February 26, 1994, pp. 508-10
  5. Nomura, Abraham, et al. Helicobacter pylori infection and the risk for duodenal and gastric ulceration. Annals of Internal Medicine, Vol. 120, No. 12, June 15, 1994, pp. 977-81
  6. Barbezat, Gilbert O. The current status of Helicobacter pylori as a pathogen in upper gastrointestinal tract. New Zealand Medical Journal, November 23, 1994, pp. 478-80
  7. Harris, Adam and Misiewicz, J.J. Hitting H pylori for four. The Lancet, Vol. 345, April 1, 1995, pp. 806-07
  8. Treatment of Helicobacter pylori infection in peptic ulcer disease (letters to the Editor), The New England Journal of Medicine, Vol. 334, No. 7, February 15, 1996, pp. 473-74
  9. Soll, Andrew H. Medical treatment of peptic ulcer disease. Journal of the American Medical Association, Vol. 275, No. 8, February 28, 1996, pp. 622- 29
  10. Neri, M.C., et al. Prevalence of Helicobacter pylori infection in elderly inpatients and in institutionalized old people: correlation with nutritional status. Age and Ageing, Vol. 25, January 1996, pp. 17-21
  11. Replogle, Marilyn, et al. Increased risk of Helicobacter pylori associated with birth in wartime and post-war Japan. International Journal of Epidemiology, Vol. 25, No. 1, February 1996, pp. 210-14
  12. Wilcox, C. Mel, et al. Striking prevalence of over-the-counter nonsteroidal anti-inflammatory drug use in patients with upper gastrointestinal hemorrhage. Archives of Internal Medicine, Vol. 154, January 10, 1994, pp. 42-46
  13. Langman, M.J.S., et al. Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs. The Lancet, Vol. 343, April 30, 1994, pp. 1075-78
  14. The EUROGAST Study Group. An international association between Helicobacter pylori infection and gastric cancer. The Lancet, Vol. 341, May 29, 1993, pp. 1359-62
  15. Tatsuta, Masaharu, et al. The association of Helicobacter pylori with differentiated-type early gastric cancer. Cancer, Vol. 72, No. 6, September 15, 1993, pp. 1841-45
  16. Dixon, Mike. Acid, ulcers, and H pylori. The Lancet, Vol. 342, August 14, 1993, pp. 384-85
  17. Bolin, Terry D., et al. Helicobacter pylori and gastric neoplasia: evolving concepts. The Medical Journal of Australia, Vol. 163, September 4, 1995, pp. 253-55
  18. Gremse, David A. and Sacks, Alan I. Symptoms of gastritis due to Helicobacter pylori in children. Southern Medical Journal, Vol. 89, No. 3, March 1996, pp. 278-81
  19. Sheu, Bor-Shyang, et al. Long-term outcome of triple therapy in Helicobacter pylori-related nonulcer dyspepsia: a prospective controlled assessment. American Journal of Gastroenterology, Vol. 91, No. 3, March 1996, pp. 441-47
  20. Patel, P., et al. Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors. British Medical Journal, Vol. 311, September 16, 1995, pp. 711-14
  21. Association of Helicobacter pylori infection with coronary heart disease (letters to the Editor), British Medical Journal, January 27, 1996
  22. Tebbe, Beate, et al. Helicobacter pylori infection and chronic urticaria. Journal of the American Academy of Dermatology, Vol. 34, No. 4, April 1996, pp. 685-86
  23. Canadian Pharmaceutical Association, CPS Compendium of Pharmaceuticals and Specialties, 28th edition, 1993, Ottawa
  24. Lindquist, Marie and Edwards, I. Ralph. Endocrine adverse effects of omeprazole. British Medical Journal, Vol. 305, August 22, 1992, pp. 451-52
  25. Garcia Rodriguez, Luis Alberto and Jick, Hersehl. Risk of gynaecomastia associated with cimetidine, omeprazole, and other antiulcer drugs. British Medical Journal, Vol. 308, February 19, 1994, pp. 503-06
  26. Parkes, Andrew J. Helicobacter pylori: how often are eradication therapies prescribed? The Medical Journal of Australia, Vol. 163, September 18, 1995, p. 334
  27. Business Week, January 8, 1996, p. 56
  28. Somal, N. Al, et al. Susceptibility of Helicobacter pylori to the antibacterial activity of manuka honey. Journal of the Royal Society of Medicine, Vol. 87, January 1994, pp. 9-12
  29. Willix, D.J., et al. A comparison of the sensitivity of wound-infecting species of bacteria to the antibacterial activity of manuka honey and other honey. Journal of Applied Bacteriology, Vol. 73, 1992, pp. 388-94
  30. Huwez F.U., et al. Mastic gum kills Helicobacter pylori. New England Journal of Medicine, 1998 Dec 24;339(26):1946.
  31. English, H.K., et al. The effects of manuka honey on plaque and gingivitis: a pilot study. Journal of the International Academy of Peridontology, 2004 Apr;6(2):63-7.
  32. White, R. Manuka honey in wound management: greater than the sum of its parts? Journal of Wound Care, 2016 Sep;25(9):539-43.
  33. Allen, K.L., et al. A survey of the antibacterial activity of some New Zealand honeys. J. Pharm. Pharmacol., Vol. 43, 1991, pp. 817-22
  34. Molan, Peter. Personal communication to Hans R. Larsen, April 11, 1996
  35. Dabos, K.J. et al. The effect of mastic gum on Helicobacter pylori: a randomized pilot study. Phytomedicine 2010 Mar;17(3-4:296-9.
  36. Kartalis A, et al. Effects of Chios mastic gum on cholesterol and glucose levels of healthy volunteers: A prospective, randomized, placebo-controlled, pilot study (CHIOS-MASTIHA). European Journal of Preventive Cardiology, 2016 May;23(7):722-9.
  37. Triantafyllou A, et al. Anti-inflammatory activity of Chios mastic gum is associated with inhibition of TNF-alpha induced oxidative stress. Nutrition Journal, 2011 Jun 6;10:64.
  38. Li S, et al. Chios mastic gum extracts as a potent antitumor agent that inhibits growth and induces apoptosis of oral cancer cells. Asian Pacific Journal of Cancer Prevention, 2011;12(7): 1877-80.
  39. Giaginis C and Theocharis S. Current evidence of the anticancer potential of Chios mastic gum. Nutrition and Cancer, 2011 Nov;63(8): 1174-84.
  40. Dabos K.J., et al. Is Chios mastic gum effective in the treatment of functional dyspepsia? A prospective randomized double-blind placebo controlled trial. Journal of Ethnopharmacology, 2010 Feb 3;127(2):205-9.


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