International Health News

Vitamin E intake and atherosclerosis

DALLAS, TEXAS. The first step in the development of atherosclerosis is believed to involve oxidation of low-density lipoprotein (LDL). Vitamin E is known to slow down this oxidation process significantly. Research has shown that a minimum intake of 400 IU/day of synthetic vitamin-E (equivalent to 130 IU/day of natural vitamin E) is required to produce a significant effect. Now researchers at the University of Texas Southwestern Medical Center report that a daily intake of 1200 IU of synthetic vitamin E is 2 to 3 times more effective in decreasing the oxidative susceptibility of LDL than is a daily dose of only 400 IU. They also point out that vitamin E at dosages of 1200 IU/day have significant antiatherogenic effects on monocytes and/or macrophages, important cells in atherosclerosis development. NOTE: This study was supported in part by Hoffman-LaRoche, the major manufacturer of synthetic vitamin E. Editor's Note: Vitamin E derived from natural sources is three times as effective as synthetic vitamin E, thus 400 IU/day of natural vitamin E is equivalent to 1200 IU/day of the synthetic version.
Fuller, Cindy J., et al. Effects of increasing doses of alpha-tocopherol in providing protection of low-density lipoprotein from oxidation. American Journal of Cardiology, Vol. 81, January 15, 1998, pp. 231-33

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