Vitamin E: Your Heart's Best Friend
by Hans R. Larsen, MSc ChE
If Hans Christian Andersen had been into vitamins he could have written "The Ugly Duckling" about vitamin E and he would have been right on the mark. Although vitamin-E is now a "beautiful swan" it certainly was not born that way.
Drs. Evan and Wilfrid Shute of London, Ontario, Canada were the first medical doctors to realize that an adequate vitamin E status is vital to the health of the heart. In 1945 they discovered that 200 IU per day of vitamin E was beneficial in reversing heart disease and in treating angina pectoris. By 1954 the Shute brothers had treated over 10,000 heart disease patients with miraculous results(1). Unfortunately, when they tried to publish their findings in medical journals their scientific papers were rejected and the medical establishment continued to ignore their findings for another 40 years. A glimmer of hope occurred in 1959 when the United States Food and Drug Administration (FDA) formally recognized that vitamin E was indeed essential to human health.
Most Powerful Antioxidant
The evidence that vitamin E can prevent and reverse heart disease is now incontrovertible. In 1992 researchers at the University of Texas reported that vitamin E protects against atherosclerosis (hardening of the arteries) by preventing oxidation of the low density lipoprotein fraction of blood(14). In 1993 researchers at the Harvard Medical School released a study showing that vitamin E supplementation prevents heart disease. Nurses who took more than 100 IU/day of vitamin E for more than two years reduced their risk of heart disease by 41 per cent. A related study involving almost 40,000 male health professionals showed that men who supplemented with between 100 and 250 IU/day reduced their risk of heart disease by 37 per cent. Vitamin E is also highly beneficial in the treatment of intermittent claudication and recent research has confirmed its ability to prevent and, in some cases, reverse the progression of atherosclerosis(13,15-18).
Vitamin E is also highly effective in warding off a heart attack. Researchers at Cambridge University in England reported in 1996 that patients who had been diagnosed with coronary atherosclerosis could lower their risk of having a heart attack by 77 per cent by supplementing with 400 IU or 800 IU/day of natural source vitamin E(19). Very recently researchers at the Toyama Medical University in Japan reported that patients with unstable angina can reduce their risk of angina attacks by a factor of six by supplementing with vitamin E (300 mg/day of alpha-tocopherol acetate)(20). Supplementation with vitamin E has also been found useful in preventing complications after heart surgery and helps slow the restenosis (reblockage) of arteries subjected to angioplasty(16,17,21).
The evidence supporting vitamin E's efficacy in preventing and reversing heart disease is indeed overwhelming. However, vitamin E has many other benefits. Daily supplementation with 400 IU of vitamin E and 600 mg of vitamin C can reduce the risk of developing cataracts by 50 per cent(22). A low intake of vitamin E is a risk factor for the development of diabetes (non-insulin-dependent, Type II) and supplementation has been found to be beneficial for diabetics(23,24). Several studies have shown that vitamin E supplementation improves longevity and may have a protective effect against both Alzheimer's and Parkinson's diseases(25-29).
Vitamin E supplementation (400 IU/day) improves the immune system response in both young and older people, is helpful in the treatment of cystic fibrosis and arthritis, and applied topically has even been found to cure dermatitis(21,30-32). Vitamin E is also helpful in cancer prevention. Scientists at the National Cancer Institute found that supplementation with vitamin E cuts the risk of oral cancer by 50 per cent. Non-smokers can reduce their risk of developing lung cancer by taking vitamin E and men can reduce their risk of colon cancer by 65 per cent by increasing their intake of vitamin E(33-36).
Large, well-controlled studies of vitamin E supplementation have shown the vitamin to be non-toxic in intakes as high as 3200 IU/day(40,44). However, most researchers caution against daily intakes higher than 800-1200 IU/day for extended periods(37,38,41). It is also recommended that the progression to a daily dose of 400 IU be gradual as should any decrease in intake. Some very recent research has shown that vitamin E in dosages higher than 1600 IU/day may have a prooxidative effect. However, this effect can be avoided by always taking adequate amounts of vitamin C when supplementing with vitamin E(45,46).
There are some cases in which high dosages (more than 30 IU/day) of vitamin E are contraindicated. Medical advice concerning dosage should be sought by individuals having high blood pressure, those taking anticoagulant drugs (Coumadin, warfarin) or having a tendency to prolonged bleeding, those having a vitamin K deficiency, and those suffering from rheumatic heart disease, an overactive thyroid or diabetes(21,37,40).
Inorganic iron (ferrous sulphate) destroys vitamin E and birth control pills deactivate it to some degree. So vitamin E should be taken with the main meal (to optimize absorption) and at least six hours before or after taking an iron supplement or a birth control pill.Supplementation is Essential
Natural vitamin E comes in several forms; d-alpha-tocopherol (100 mg=149 IU), d-alpha-tocopherol acetate (100 mg=136 IU), and d-alpha-tocopherol succinate are the most common. The "d" designation in front indicates that the products are derived from natural sources such as vegetable oils or wheat germ. A prefix of "dl", such as dl-alpha-tocopherol, shows that the vitamin has been synthesized from a petroleum base. Synthetic vitamin E is far less effective than natural vitamin E. Recent research has also shown that expensive water-soluble forms of vitamin E are no more effective than the regular fat-soluble forms(21,30,47-49).
The benefits of an adequate vitamin E intake cannot be over-emphasized. Unfortunately, it is quite impossible to get enough vitamin E from even the most well-balanced diet. To obtain a daily vitamin E intake of 400 IU it would be necessary to consume 200 cups of brown rice, 10 cups of almonds, 80 cups of cooked spinach or 12 tablespoons of unrefined, fresh wheat germ oil every day. Supplementation is clearly necessary. A daily intake of 400 IU/day of natural vitamin E combined with 250-1000 mg/day of vitamin C will help protect you against heart disease, cancer, and many other degenerative diseases.